Garrison graduated from Freehold High School in 1970, where he began his acting career on the school's stage. He was inducted in the school's Hall of Fame in 2007. Garrison graduated summa cum laude from Boston University's College of Fine Arts in 1974. Following graduation, he became a member of the resident company at Arena Stage in Washington, D.C. for several years.
Garrison has also appeared in numerous roles on television. In 1984–85, he starred as Norman Lamb on the sitcom It's Your Move, opposite Jason Bateman. In 1987, Garrison landed his best-known role, portraying Steve Rhoades, next-door neighbor to the Bundy family on the popular sitcom Married... with Children.
Other television credits include Unbreakable Kimmy Schmidt, Madame Secretary, The West Wing, 30 Rock, Law & Order, The Practice, Without a Trace, Everybody Loves Raymond, NYPD Blue, Judging Amy, Murphy Brown, Murder, She Wrote, L.A. Law, Tom Clancy's Op-Center, The Good Wife and, for PBS Great Performances, On the Town with the London Symphony Orchestra and Ira Gershwin at 100: A Celebration at Carnegie Hall. Garrison also participated in several installments of Pyramid as a Celebrity guest, most notably helping a contestant win $100,000 during a Tournament episode of The $100,000 Pyramid in 1988 .
He originated the role of The Wizard in the original touring company of Wicked when it began on March 8, 2005. He finished his year-long run on March 6, 2006. He then starred as the Wizard in the Broadway company from April 4, 2006 replacing Ben Vereen. After 15 months in the role he played his final performance on July 8, 2007. Then he temporarily starred in the Chicago company from September 30–October 28, 2007, and then starred in the Los Angeles company beginning August 26, 2008, until its closure on January 11, 2009. He played the role in the San Francisco production, which officially opened on February 6, 2009 and played his final performance with the production on May 31, 2009 in order to pursue a role in a new play.
Although he is known for his television roles and he continues to be seen frequently in guest-starring roles on television today, Garrison is primarily a theatre actor, particularly in musicals. He has appeared in numerous productions around the United States, including many Broadway shows. His Broadway appearances include A Day in Hollywood / A Night in the Ukraine for which he received a Tony Award nomination, Wicked, The Visit, Titanic, Torch Song Trilogy, The Pirates of Penzance, Bells Are Ringing, A History of the American Film, and Off-Broadway in I Do! I Do!, for which he received a Drama Desk Award nomination, Dead Poets Society, Middletown, New Jerusalem, Geniuses, It’s Only a Play, By the Way Meet Vera Stark, and Silence! The Musical. In addition to the cast albums of Hollywood/Ukraine, Titanic, Bells Are Ringing, The Visit, I Do! I Do!, and On the Town, his many recordings include Songs of New York, Show Boat, Kiss Me Kate, Annie Get Your Gun, Of Thee I Sing/Let ’Em Eat Cake, Girl Crazy, You Never Know, Tell Me More, Oh! Lady! Lady!!, George and Ira Standards and Gems, and, as a guest Artist, Dawn Upshaw Sings Rodgers and Hart.”.
