Seinfeld was the founder, Bassist and vocalist for the New York hardcore heavy metal band Biohazard. Seinfeld founded the band in 1987 but left the band in early 2011. Evan was also the Bassist for the short-lived supergroup Damnocracy, featured in the VH1 reality television show Supergroup, with other members including Ted Nugent, Sebastian Bach, Scott Ian and Jason Bonham. In March 2007, Evan Seinfeld debuted his new band, The Spyderz, as an opening act for a Buckcherry performance. The band was originally named White Line Fever until it was discovered that a UK band already owned the name. The Spyderz also featured Guitarist John Monte, formerly of Ministry, M.O.D. and The Disparrows vocalist Daniel Weber. In October 2008, Seinfeld briefly joined Tattooed Millionaires as a Bassist and co-vocalist.
After a three-year relationship, Seinfeld married Tera Patrick in a small ceremony on January 9, 2004. The ceremony was held in Las Vegas where they were attending the 2004 AVN Awards show. The couple announced on September 30, 2009 that they were ending their marriage, but that they would remain Business partners.
He is one of the characters in the book Sex Tips from Rock Stars by Paul Miles, published in July 2010 from Omnibus Press.
In 2011 Seinfeld joined Attika7, a band featuring former members of Walls of Jericho, Static-X, Soulfly, and Possessed. The band's debut album, Blood of My Enemies, was released on July 31, 2012.
