Morgan initially entered the porn industry as a means to pay off her bail and plea bargain after being arrested in 2000 for transporting over 100 pounds (45 kg) of marijuana from Mexico into the United States. Her first sex scene was in Ed Powers' Dirty Debutantes 197 in 2001. She unofficially retired from adult films in 2008. It was made official when she married a year later. In September 2015, she ended seven years of retirement by announcing her signing with Nexxxt Level Talent and began shooting productions in Los Angeles and Miami.
In 2008, Morgan made a guest appearance on HBO's Entourage playing herself. She made her first mainstream feature film appearance in Kevin Smith's 2008 comedy, Zack and Miri Make a Porno.
From 2011 to 2013, she hosted Having Sex, With Katie Morgan on S.I.R! at Smodcast.com.
She has been featured on HBO's A Real Sex Xtra: Pornucopia – Going Down in the Valley, Katie Morgan on Sex Toys, Katie Morgan: Porn 101, Katie Morgan's Sex Tips: Questions, Anyone?, and in the HBO documentary film Katie Morgan: A Porn Star Revealed, in which she describes having chosen the surname "Morgan" in reference to the alcoholic beverage Captain Morgan's Rum and the first name "Katie" in reference to the real first name of the Scarlett O'Hara character in Gone with the Wind. She typically would host such shows completely naked except for a pair of high heels.
In 2016 she appeared in "Vixens from Venus."