Campbell was signed by the Minnesota Vikings as an undrafted free agent in April 2002. He made the team out of training camp, and went on to appear in six games including two starts for the Vikings during his rookie season despite spending some time on the practice squad. He accumulated 13 catches for 176 yards and three touchdowns on the year.
Campbell started six of the 15 games in which he appeared in 2003. He went on to have the best season of his career, catching 25 catches for 522 yards and four touchdowns. He also carried the ball 10 times for 71 yards and returned five kickoffs for 101 yards. In 2004, Campbell appeared in all 16 games of the regular season for the first time in his career. He started three games and on the year caught 19 catches for 364 yards and a score. He also returned 35 kickoffs for 760 yards.
After spending 2005 out of the NFL, Campbell worked out for the Miami Dolphins in January 2006. He was signed by the team in March and given a chance to earn the team's No. 3 receiver job behind starters Chris Chambers and Marty Booker. However, a quadriceps injury hurt his chances to impress the coaching staff, and after an injury settlement with the team was reached Campbell was released.
Despite a new head coach in Miami, Campbell was re-signed by the team on March 8, 2007. However, he was let go on July 6, before training camp opened.
On June 2, 2008, Campbell signed with the Edmonton Eskimos. Campbell led the CFL with a 22.6 yards per reception average and he caught 54 passes for 1,223 yards and scoring seven touchdowns.
On January 9, 2009, Campbell signed a one-year contract with the Tampa Bay Buccaneers. He was placed on the IR in August of that year and then later released on October 20, 2009.
Campbell reportedly signed a multi-year contract with the Eskimos at the end of the 2009 CFL season. On June 11, 2010, it was announced that Campbell had rejoined the team and would report to training camp.
