Lee Yoo-ri met her husband, a missionary theologist, through bible study in 2008. They started dating in 2009 and married in September, 2010.
In 2011, Lee and fellow Actress Lee Soo-kyum co-launched female apparel shopping mall 'Miss Today'.
In 2014, Lee won the Grand Prize at MBC Drama Awards, gaining 385,434 (about 54%) out of 712,300 votes sent in by the viewers. She was also ranked in the top five of Gallup Korea's "Actor of the Year", climbing to the second place just behind Kim Soo-hyun.