Schulze was featured on Fox's legal drama, Justice and has guest-starred on Law & Order, JAG, CSI: Crime Scene Investigation, The West Wing, NCIS, Oz, Frasier, NYPD Blue, Cold Case, Boston Legal, Journeyman, Numb3rs, Mad Men, Criminal Minds, The Closer, Terminator: The Sarah Connor Chronicles, Suits and Z Nation. His film appearances include New Jersey Drive (1995), Clockers (1995), Don't Say a Word (2001), and the David Fincher films Panic Room (2002) and Zodiac (2007). Schulze next appeared as Michael Burnett in Rambo, the 2008 fourth installment of the Rambo film saga.
Schulze co-starred as Eddie Walzer in the Showtime dark comedy series Nurse Jackie, which premiered in June 2009.
