She rose to prominence as Chairwoman of the Convention People's Party and was the first woman to chair one of Ghana's major political parties.
She was a bank clerk with the Bank of India's London headquarters and then pursued a journalism career for a time with Egyptian newspaper Al-Ahram.
She was hailed as "the new Mandela" by The Huffington Post upon her historic 2008 election.
Her father was Ghana's first president, Kwame Nkrumah, and her mother, Fathia Rizk, was Egyptian.
She met with former U.S. president Bill Clinton at the XII World Summit of Nobel Peace Laureates in 2012.