Alexis began her NHRA career in 2005, initially competing in the Super Gas category before moving into a rear engine Super Comp dragster. Eight months after her NHRA debut, she went on to win the Sportsman Nationals in Fontana, California.
In 2009, Alexis built her own racing team, Stealth Motorsports. At the 2011 NHRA North West Fall Nationals, she won her first ever NHRA national event win in TAFC, becoming the second woman ever to do so. She co-owned and operated the team for three years, leaving in 2011 to join Kalitta Motorsports as their fourth member and second Funny Car driver. This move coincided with her transition to racing a nitro powered Funny Car at the 2011 Texas Fall Nationals.
In 2012, Alexis raced her first final-round appearance at Bristol. That year she also set both a career best for time with a run of 4.032 and speed of 319.07 at Reading.
In late 2012, DeJoria became engaged to American television personality and motorcycle customizer Jesse James. They married on March 24, 2013 at the estate of her father, Entrepreneur John Paul DeJoria.
In 2014, Alexis became the first woman ever to make a sub-four second run, with a 3.997-second ET In Pomona, Calif. during the NHRA Winternationals. At her next race in Phoenix, Alexis won her first race in the Funny Car category. In March 2014, she picked up the second win of her professional career in Las Vegas. That May, she broke a Funny Car track record at Atlanta Dragway (4.012-second ET) while earning her the Number One qualifier position. That summer, she went on to break Brainerd International Raceway’s Funny Car ET record when she ran a 4.010-second pass and then reset her own record with a 3.998-second run, the first sub-four second Funny Car run recorded at BIR. In September she won the U.S. Nationals in Indianapolis. June 7, 2015 advanced to the finals in Nitro Funny Car in the Summernationals at Englishtown NJ.
