The Venture Bros. was conceived as a short comics story for a comics anthology by Monkeysuit Press, of which McCulloch is the Editor. Working on The Tick (and listening to J.G. Thirlwell's first Steroid Maximus album) helped McCulloch translate the story into cartoon form. He wrote the first draft in 2000 while he was attempting to pitch something else to Comedy Central, which turned it down. At the time, he was also working as a storyboard Artist for Mo Willems's Sheep in the Big City and for PB&J Otter.
After this, The Tick was picked up in its live action form, and McCulloch moved to California. During this he met Patrick Warburton, who later went on to voice Brock Samson. When The Tick was canceled, he moved back to New York City and pitched a revised version of The Venture Bros. to Comedy Central again. Though it was turned down again, he contacted Jeff Nodelman of Noodlesoup Productions (which became World Leaders Entertainment). Adult Swim later picked up the series and the pilot was produced in 2003.
