Hartwell was drafted by the Baltimore Ravens in the fourth round of the 2001 NFL Draft. He played for the Ravens from 2001 to 2004. He never missed a game, though he was limited to special teams in 2001. He finished his career with the Ravens with 337 tackles, six sacks and one interception.
Court records show that Lisa Wu-Hartwell and Ed Hartwell borrowed $2.9 million to buy their suburban mansion in June 2007. Just over two years later, Bank of America paid $1.9 million for the house at a foreclosure sale at the Forsyth County, Georgia courthouse, after the Hartwells defaulted on their adjustable-rate mortgage from the bank.
Hartwell signed with the Oakland Raiders on May 2, 2008. He was released by the team on August 13 after the team signed punter Glenn Pakulak.
Hartwell signed with the Las Vegas Locomotives in 2010.
Ed Hartwell filed for divorce on August 24, 2011; it was finalized October 7, 2011, with the court document giving her name as Sharon Millette Hartwell.
On New Year's Day 2016, Hartwell married Actress Keshia Knight Pulliam. On July 17, 2016, Pulliam announced that she was expecting her first child, a girl, with husband Ed Hartwell. Hartwell filed for divorce on July 25, 2016.