In 2012, it was announced that Meyers-Shyer's script The Chelsea would be made into a film starring Felicity Jones and directed by Nancy Meyers. In 2017, Meyers said her daughter's project ran into casting problems, and Meyers-Shyer "just moved on from it."
Meyers-Shyer attended high school at Crossroads School. She originally enrolled at the University of Southern California to study screenwriting, but transferred to The New School where she graduated with a degree in literature. She made her screenwriting and directorial debut with the film Home Again (2017), which stars Reese Witherspoon and was released in September.
