In 1999, with some fellow students, he founded his first band but they soon broke up. In 2008, he founded the rock band Biting Elbows, where he is a singer and Guitarist. In 2011, he appeared in the EP Dope Fiend Massacre and the debut album Biting Elbows.
In 2013, Naishuller appeared in the single Bad Motherfucker, where he also directed the music video. The first-person amateur video went on to be a viral hit online with over 20 million views and was, among others, praised by Darren Aronofsky.
Shortly thereafter, Naishuller began shooting his film-directing debut Hardcore, later renamed Hardcore Henry. The action movie was produced by Timur Bekmambetov and featured supporting roles from Sharlto Copley and Tim Roth. Naishuller functioned as a Screenwriter, Director, Producer and also took on a role as an actor. The film premiered at the Toronto International Film Festival 2015, and went on to gross $14.3 million USD, becoming one of the most successful Russian films since 1991.
