Denbo was one of the stars of the sitcom Happy Hour, playing the role of Tina Difabio. She also played Susan Jones on the Goodnight Burbank video podcast. On August 5, 2007 she returned as co-anchor on the show. Her pilot Ronna & Beverly (based on the popular stage show she performs with Jessica Chaffin at the UCB) aired as a comedy special on the Showtime network in December 2009. In 2011, Denbo and Chaffin started the Ronna and Beverly comedy podcast where they interview different celebrities each week.
In 2010, she co-starred as Maggie Lefferts on the FX series Terriers. She has frequently appeared in comedy segments on The Late Late Show with Craig Ferguson. She has made guest appearances on shows such as Curb Your Enthusiasm, Happy Endings, The Life & Times of Tim, Reno 911!, Suburgatory, Bad Judge, Mike & Molly, Weeds, How I Met Your Mother, Mighty Med, Mulaney, Speechless and The Real O'Neals.
In December 2011, Denbo and Kerri Kenney-Silver made a pilot for Comedy Central called Dame Delilah’s Rabbit Hole Ranch based on a web-series they previously created and starred in. Her screenplay for Best Buds was sold to Vendome Pictures in 2010 with Natalie Portman attached to produce and star. Denbo is also a contributing Writer for The Huffington Post.
