Wilkison played Riley Colson on the ABC soap One Life to Live from February 24, 2003 through June 8, 2005.
Wilkison appeared in the hit Broadway show Rent from December 27, 2004 until December 17, 2005. He started as a swing and took over the role of Roger Davis. He has returned to the show several times since 2006, and was in the final cast, playing Gordon and others. He was also a Mark and Roger understudy.
From 2014 to 2015, Wilkison played Pete Collins on Nashville. He also played Colin McNichol on Younger from 2016 to 2017. Other TV roles include Hank on Rescue Me (2006), Gregg Robinson on Law & Order (2006), Terry on Nurse Jackie (2009), and Colin on The Blacklist in 2018.
