In 2009, Lusi played Princess Li Hua in KRU Studios' The Malay Chronicles: Bloodlines. The film required Lusi to speak Bahasa Melayu, which she had to learn phonetically. Lusi has starred in independent British films Jack Falls opposite Jason Flemyng, Dexter Fletcher and Olivia Hallinan, Breathe (2010) with Ricci Harnett, and Bollywood action film Tezz with Anil Kapoor.
In 2012, Lusi joined the cast of the BBC's BAFTA award-winning medical drama series Holby City, making her debut in Series 14. She played Tara Lo. In 2013, she left the cast when her character died during neurosurgery. Her final episode aired on 16 April 2013. Her other television credits include Law & Order: UK and Josh.
She was the subject of the BBC1 My Chinese New Year which was broadcast on 1 March 2015.
Since January 2016 Lusi has starred as Lily-Anne Lau in Sky 1's Stan Lee's Lucky Man. Additionally she joined the cast of Scott & Bailey for Series 5, playing the part of new character DC Anna Ram.
In April 2017, it was announced that Lusi had been cast in the Warner Bros. film Crazy Rich Asians starring Constance Wu and Michelle Yeoh.
