Cooke was born in Philadelphia, Pennsylvania and attended Harriton High School, a small public high school in Rosemont, a suburb of Philadelphia. He was a member of Harriton Theater Company and directed a show his senior year. He has received acting awards including the James Pendleton Foundation Prize for Outstanding Achievement in Performance and the Judith & Milton R. Stark Scholarship. Cooke graduated from the University of California, Los Angeles in 2004, where he majored in theater. He has been married to Eleisha Eagle since April 2011.
He played the lead role of Nate Solomon in NBC's 2005 sitcom Committed. He appeared in guest roles on Without a Trace, Century City, Once and Again, 10-8, and Dragnet.
In 2006, Cooke co-starred in the film Wasted as Dixon, alongside Eddie Kaye Thomas and Kip Pardue. Cooke also played Christina Milian's love interest, Eddie, in Snowglobe. He played Eric in Young People Fucking (2007). He is set to appear in the upcoming film A Fork in the Road. He had a small role in I Love You, Man as Alan, a straight married man in a relationship with Robbie Klaven (played by Andy Samberg). Cooke was one of the lead roles in Quarantine 2.
He played Dan Stonewater on the final episode of Scrubs and Rabbi Feldman on the final episode of The King of Queens. In 2009, Cooke played Auggie Harris in Season 6 Episode 7 on Numb3rs. Cooke played Ben Coles on Better with You, a sitcom which began in 2010 and was cancelled after 22 episodes.
Cooke starred as Andy in the 2010 comedy Group Sex, alongside Greg Grunberg and Odette Yustman. Cooke played the lead role as Ron in the 2008 direct-to-DVD film Bachelor Party 2: The Last Temptation.
On November 10, 2015, he released his debut album 'fō under the stagename "fō". It was executively produced by Cooke and Erik Kertes.
In 2016, Cooke was cast in the La Jolla Playhouse premiere of Pulitzer Prize winner and Tony Award nominee Ayad Akhtar's Junk: The Golden Age of Debt as "Robert Merkin." It will be directed by Tony Award winner Doug Hughes and premiere on July 26, 2016.
