From 1994 to 2009 she had a regular role as nurse Lily Jarvik on the NBC television series ER, for which she has won the Screen Actors Guild Award for Best Ensemble in a Drama Series four times. She has appeared in many films such as The Best Little Whorehouse in Texas, Mighty Joe Young, The Shadow, The New Age, The Doctor and Extraordinary Measures. Lily has guest-starred in over 25 television shows including Teen Wolf, Criminal Minds, Shameless, NCIS L.A., Judging Amy, Ally McBeal, Family Ties, Star Trek: Deep Space Nine and Chicago Hope. She is also an award-winning theatre Actress, performing in New York, Los Angeles and other regional theatres around the country.
In 2012 Mariye was chosen to participate in the Disney/ABC/DGA Directing Program. In 2016 she directed Episode 14, Season 4 of ABC's Nashville (season 4) and Episode 4 after Nashville (season 5) moved to CMT. She also directed an episode of Season 2 of Amazon's "Just Add Magic" and episode 17, Season 4 of Freeform's "The Fosters."
She has written several full-length screenplays, one of which, The Shangri-la Cafe, was accepted into the second round of the application process for development in the Sundance Feature Film Labs. The Shangri-la Cafe won Best Screenplay at the Ohio International Independent Film Festival and the Gaffers Film Festival, and won her a grant from the AFI Conservatory's prestigious Directing Workshop for Women, 13th Cycle. While at AFI she produced and directed an award-winning short film version of the script (Best Short Film Award - Moondance International Film Festival, Best Screenplay Award - Brussels Independent Film Festival). The short film version of The Shangri-la Cafe was included on a DVD release of AFI shorts entitled Celebrating AFI.
In 2017 she participated in The CBS Directing Initiative. Also in 2017, Mariye directed episodes of Chicago P.D. (TV series), NCIS: Los Angeles and helmed her third episode on Nashville (season 6).
In 2018 she received a DGA Award Nomination at the 70th Annual DGA Awards for Outstanding Directorial Achievement in Children’s Program for her work on "Just Add Magic.
