Mira was born in Stoneham, Massachusetts on August 5, 1983 and grew up in Lowell, Massachusetts. He is the youngest of four children. His parents are John and Mary Mira. He has two older sisters Kimberly and Julie, and an older brother John. He was raised Catholic, and attended Lowell Catholic High School. After high school he attended local colleges. He left Massachusetts for Los Angeles in 2007 to pursue a career in comedy.
Beginning in March 2012, Matt began co-hosting an occasional podcast with film Producer Scott Mosier called FEaB (Four Eyes and Beard), a joint production of Nerdist Industries and SModcast.com.
Since October 2013, Mira has been writing for the Chris Hardwick hosted @midnight on Comedy Central.
On June 19, 2015, Kevin Smith announced via Facebook that he and Mira "will provide a commentary track for every single episode of Frasier" on a new podcast entitled Talk Salad & Scrambled Eggs - Frasier Reconsidered w/ Matt Mira & Kevin Smith.
As of 2016, Mira currently is writing for The Goldbergs on ABC. He also hosts a podcast with his wife Doree Shafrir about their journey about making a baby with science called Matt & Doree's Eggcelent Adventure.
On September 22, 2017, Matt was named host of After Trek, a live after-show companion to Star Trek: Discovery broadcast on CBS All Access.
