Ganz graduated from Hackett Catholic Central High School in Kalamazoo, Michigan in 2002.
In 2006 Ganz graduated with honors from the University of Michigan, where she was editor-in-chief of The Every Three Weekly. After completing her junior year at the university, she interned at Mad Magazine in New York City. Ganz had planned to move back to Michigan after her internship was over, but Mad's editor-in-chief John Ficarra encouraged her to remain in New York and pursue comedy writing. She returned to New York and became assistant Editor at The Onion and was later promoted to associate Editor.
In 2008 Ganz was featured on an episode of This American Life along with other Onion staff members. An agent from United Talent Agency heard the broadcast and suggested that she move into television writing. In summer 2009 Ganz left her job at The Onion and moved to Los Angeles to become a Writer for the Comedy Central Sketch show Important Things with Demetri Martin. In 2010, she began writing for the NBC comedy series Community.
In 2013, after the shortened season 4 of Community had wrapped, Ganz joined the writing staff of the ABC series Modern Family.
In 2016, Ganz announced on her Instagram that she had been hired as a Writer for It's Always Sunny in Philadelphia.
In 2018, during a Twitter exchange with Community creator and executive Producer Dan Harmon, Ganz accused Harmon of having engaged in inappropriate behavior toward her during their time on the show together. Harmon detailed his behavior on an episode of his podcast, Harmontown, in which he went into detail about his wrongdoings which included making advances on her and then mistreating her after she turned him down. Ganz said that she felt vindicated by the admission and accepted his apology, urging her Twitter followers to Listen to this episode of Harmontown, and calling it a "master class in how to apologize", ultimately forgiving him.
