Starred in Tim Burton's films Beetlejuice, Batman and Batman Returns as well as in the comedy films Multiplicity and Mr. Mom. He has also voiced characters in the animated films Cars, Minions and Toy Story 3. His role as Riggan in the 2014 film Birdman earned him a Golden Globe Award for Best Actor in a Motion Picture, Musical or Comedy.
Raised as the youngest of seven children, he attended Montour High School. He worked as a TV cameraman for a local public television station in Pittsburgh. His real surname was Douglas, but fearing confusion with another actor, he chose to use the name Keaton.
He hosted an episode of Saturday Night Live in 1982, then went on to host again in 1992 and 2015.
He co-starred with Alec Baldwin and Geena Davis in Tim Burton's Beetlejuice.