Notable for his recurring roles on the British television comedy shows Sorry, I've Got No Head; Horne & Corden; Reggie Perrin; and Gates, he is also known for his work on the children's series Hank Zipzer. In 2015 he portrayed Tim Grimes in the film The Martian.
After studying geophysics at St. Aidan's College, Durham University, he entered Magdalene College, Cambridge's seismology doctoral program. Upon being discovered by a BBC executive while performing at the Edinburgh Fringe Festival, he ended his studies to pursue a career in comedy.
He was featured on the popular BBC Radio 4 programs Quarters and Nick Mohammed in Bits.
He was born and raised in Leeds, West Yorkshire, England.
Mohammed, Simon Bird, and Katy Wix hosted the British comedy program The King Is Dead.