Morrison took up photography at a young age. She grew up in Cambridge, Massachusetts, and graduated from Concord Academy in 1996. She then attended New York University, where she completed a double major in film and photography because she was unable to choose between the two; by the end of her degree, she had decided to concentrate on cinematography. She then attended the AFI Conservatory's graduate cinematography program and graduated with a Master of Fine Arts in 2006.
Morrison began her career in television, working on series and telefilms for a number of networks. Her cinematography on the 2005 television documentary Rikers High, about high school education within the Rikers Island prison complex, was nominated for an Emmy Award.
The 2007 independent film Palo Alto marked Morrison's debut as the primary Cinematographer on a feature film, after which she took a job as Director of photography on the MTV reality series The Hills. She worked on The Hills for two years, then shot Zal Batmanglij's Sound of My Voice, which premiered at the 2011 Sundance Film Festival. Over the next two years, she photographed Tim and Eric's Billion Dollar Movie and Fruitvale Station, which premiered at Sundance in 2012 and 2013 respectively, as well as Any Day Now (2012), Some Girl(s) (2013) and The Harvest (2013).
Morrison is a lesbian. She and her wife Rachel Garza were married in December 2011 and have one son, who was born in 2014.
At the 2013 Women in Film Crystal + Lucy Awards, Morrison was awarded the Kodak Vision Award for her work in cinematography and her collaboration with other women filmmakers. The same year, Variety named her as one of the "Up Next" in their Below The Line Impact Report, while Indiewire named her as one of their "Cinematographers To Watch".
2014 marked Morrison's first foray into directing, as she was offered the chance to direct an episode of the television series American Crime, which aired in 2015. In 2017 she became a member of the American Society of Cinematographers.
Morrison was the Cinematographer for Dee Rees's 2017 film Mudbound. For her work on the film, Morrison became the first woman to win the New York Film Critics Circle Award for Best Cinematographer, the first woman to be nominated for the feature category of the American Society of Cinematographers Outstanding Achievement Awards, and the first woman ever nominated for the Academy Award for Best Cinematography.
Morrison served as Cinematographer for Marvel's Black Panther (2018).
