A former Hooters Girl, she began her career as a professional stripper in 2008, dancing at a club called the Silver Reign, from which she took her pseudonym.
During a May 2012 holiday in Monaco with fellow adult star Brooklyn Lee, Reign encountered former United States President Bill Clinton. A photo of the adult stars and Clinton quickly went viral on the internet. After massive media attention, Reign explained the photo with Clinton was her being a fan of him and not the other way around.
In December 2013, she appeared in the independent film Blood of Redemption.
In June 2014, it was announced that Reign would be receiving her diploma from UCLA during the commencement ceremony on Saturday, June 14. Her degree is in gender studies. Jennifer Moorman, a lecturer at the Otis College of Art and Design, commented that Reign was a "thoughtful and inquisitive student who brought a unique perspective to the classroom."
In late 2016, she is active in advocacy to oppose the passing of California's "Proposition 60", which would introduce a law that sex performers must always use condoms in sex scenes.