Holmes began her film acting career with 1998's Edge of Seventeen, playing the starring role of Maggie. She followed that with roles in the movies 30 Days in 1999; The Photographer and Prince of Central Park in 2000; Seven and a Match in 2003; Pretty Persuasion in 2005; Half Nelson in 2006; and Shelter in 2007.
She appeared as a waitress/patient named Nadia on the February 14, 2011 episode of House, entitled "You Must Remember This".
She appeared as Laurel, an expectant mother carrying twins, on the February 23, 2012 episode of Private Practice, entitled "Andromeda".
