Wilcox has also appeared in the Goodman Theater production of Elizabeth Spencer's novella The Light in the Piazza as Fabrizio alongside Celia Keenan-Bolger as Clara, and in the off-Broadway production of The Great American Trailer Park Musical in 2005 as Leo/Duke. In 2006, he was performing in the Roundabout Theatre Companies off-Broadway adaption of Suddenly Last Summer, a Tennessee Williams play that opened, as George Holly; Carla Gugino and Blythe Danner are also acting in the project.
He has a small role in the movie "Interview" with Steve Buscemi and Sienna Miller, which had its U.S. premiere at the 2007 Sundance Film Festival. Wayne has also been cast in "Coram Boy", a Broadway version of the successful 2006 National Theater of London production. It is tentatively scheduled to start previews in April 2007 and premiere on May 1, 2007.
From April-June 2015, he was in the premier of Paul Gordon's "Sense and Sensibility" at Chicago Shakespeare Theatre, originating the role of Edward Ferrars.
