In Christmas 2010, TJX Companies aired a commercial for TJ Maxx and Marshalls, featuring Annie Little and the theme "There's a better way to Christmas shop".
In the Season 3 premiere ("Out of Town") of the TV drama series Mad Men, Little played an air hostess named Lorelei. On April 25 and May 3, 2011, she appeared on 90210.
In 2013, Little appeared in a commercial for the Volvo XC60.
In 2015 she appeared as humanitarian charity worker Carolyn Decker in the Castle season 7 episode "At Close Range".
