Rooney tried her hand at presenting when, in May 2006, she assisted Sir Trevor McDonald on his show Tonight with Trevor McDonald in a programme about the genetic disorder Rett syndrome, from which her younger sister suffered. She went on to make her own series for ITV called Coleen's Real Women in which she was labelled as "The nation's favourite girl next door" and looked for "real women" to front advertising campaigns as an alternative to Models.
Rooney has an exercise DVD on sale in the UK, entitled Coleen McLoughlin's Brand New Body Workout, which became a bestseller. She was paid £3 million to front the George at Asda campaign. Rooney's autobiography, Welcome to My World, was released in March 2007.
Their wedding took place in Portofino, Italy on 12 June 2008. The couple were paid a reported £2.5 million by Britain's OK! magazine for exclusive wedding information and pictures. The couple, dubbed Wayleen, moved into a new £1.3m mansion in Formby. They currently live in Prestbury, Cheshire, in a £4 million Neo-Georgian mega mansion, which has an indoor swimming pool, sweeping staircase, jacuzzi and gold-plated taps. Her favorite pop band Westlife serenaded the couple on their wedding and at the reception.
On 2 November 2009, Rooney gave birth to their first child, Kai Wayne Rooney. On 21 May 2013, Rooney gave birth to Klay Anthony Rooney. On 24 January 2016, Rooney gave birth to her third son Kit Joseph Rooney. On 15 February 2018, Rooney announced on her Twitter profile the birth of her fourth son Cass Mac Rooney.
In June 2010, Rooney struck a deal with the Retail and gambling company Littlewoods; she said of the deal: "The role is a perfect match in enabling me to select and wear my favourite styles as well as share my ideas on how to carry off the season's new trends."
Coleen Mary McLoughlin was born in Liverpool, Merseyside, to Tony and Colette McLoughlin. Tony McLoughlin, who was a bricklayer, also ran a boxing club. The McLoughlins are of Irish descent. Coleen is the eldest of four children, followed by her brothers Joe and Anthony and her adopted sister Rosie, who suffered with Rett syndrome and died on 5 January 2013 at the age of 14.