Domingo starred as Mr. Franklin Jones, Joop, and Mr. Venus, in the critically acclaimed rock musical Passing Strange, which, after a successful 2007 run at The Public Theater, opened on Broadway on February 28, 2008. He received an Obie Award in spring 2008 as part of the ensemble of Passing Strange Off-Broadway and reprised his roles in the film version of Passing Strange, directed by Spike Lee, which made its premiere at the Sundance Film Festival in January 2009. In 2010, Domingo's self-penned, one-man autobiographical play A Boy and His Soul premiered Off-Broadway at the Vineyard Theater, for which he won a Lucille Lortel Award for Outstanding Solo Show. He was also nominated for a Drama Desk Award and a Drama League Award.
Domingo starred as Billy Flynn in Chicago, the longest running revival on Broadway, and in the final collaboration by Kander and Ebb of The Scottsboro Boys, directed by Susan Stroman on Broadway in Fall 2010. For the latter role, he was nominated for the Tony Award for Best Performance by an Actor in a Featured Role in a Musical, in May 2011. When The Scottsboro Boys opened in London in Fall 2013, Domingo was nominated for the Olivier Award for Best Performance in a Supporting Role in a Musical in April 2014. He was nominated for the Fred Astaire Award for Best Principal Dancer on Broadway in 2011.
In 2015, Domingo began appearing in a recurring role on AMC's post-apocalyptic, zombie series Fear the Walking Dead, as a character named Victor Strand. In December 2015, it was announced that Domingo was promoted to series regular for Season 2 of the series.
In 2017, Domingo joined Academy of Motion Picture Arts and Sciences as a member of the Actors' Branch.
