Star of the weekly YouTube series My Drunk Kitchen, which features her attempting to cook in increasing stages of drunkenness. She has over 2.5 million subscribers on her MyHarto YouTube channel. In 2014, My Drunk Kitchen won a Streamy Award for Best Comedy series.
She came up with the idea for her show during a video chat with a friend who was complimentary of her cooking skills.
She created the "Have a Hart Day" initiative of community Service events.
She has a sister named Naomi and a half-sister named Maggie. She grew up in a conservative Christian family and repressed her homosexuality until she moved to New York. In September 2015, she announced in a Diva Magazine interview that she and fellow YouTuber Ingrid Nilsen were in a relationship. She began dating Ella Mielniczenko following her breakup with Nilsen.
She, Grace Helbig, and Mamrie Hart are good friends, and are affectionately known to their fans as the Holy Trinity of YouTube.