His big break in films came with a role in Rose Bernd in 1956. He was then cast in the major role of Colonel Rossdorf in the production of The Devil Strikes at Night the following year - a role which saw him awarded a Best Actor accolade. A series of successful roles followed, including The Doctor of Stalingrad, Der Transport (Destination Death), Die Brücke des Schicksals and the comedy Babette Goes to War with Brigitte Bardot. He achieved critical international acclaim for his role as Colonel Muller in the Roberto Rossellini production of General della Rovere (1959), with the film winning the Golden Lion at Venice that year.
Messemer is probably best known for his role as Oberst von Luger, the Kommandant in The Great Escape (1963). The film had a star-studded cast, but it was Messemer, relatively unknown outside Europe, who uttered the film's most famous line (to Steve McQueen/Capt. Hilts): "It looks, after all, as if you will see Berlin before I do."
A heavy lifelong smoker, Messemer suffered throat cancer during the 1980s, and surgery left his voice at only a whisper. Forced to retire from acting, he appeared on German television for the last time in 1989, in a production with Agnes Fink.
