In 2003, Jacobs played Alice in the EastEnders spin-off Perfectly Frank.
In 2004, Jacobs joined the cast of the BBC medical drama series Holby City as fun-loving nurse, turned Ward Sister, Donna Jackson. In 2011, Jacobs left the show and the role of Donna Jackson. She is set to reprise her role in June 2017.
In Autumn 2005, Jacobs appeared in the third series of Strictly Come Dancing, dancing with professional partner Andrew Cuerden. However, the couple were eliminated in the second week of the contest and finished in 11th place on the show.
In 2015, Jacobs appeared in an episode of the ITV drama Midsomer Murders as Police Constable Carolyn Florrie. She voiced Amaya in the fifth episode of the video game Game of Thrones.
In October 2014-March 2018, Jacobs played the role of Amber on CBBC children's television program Millie Inbetween. However, due to her return to Holby City, she will serve as a recurring character in the fourth series.
