Sams has had recurring roles on television series such as Strong Medicine, Law & Order and CSI. He appeared on Broadway in the 1992 musical Five Guys Named Moe, the 1993 motion picture Fly By Night and in the 1997 motion picture Soul Food.
As of 2005, Sams had a recurring role on Rob Thomas's Veronica Mars as a baseball player named Terrence Cook. His Cupid co-star Paula Marshall previously had a recurring role on the show, and Thomas has stated that - at some point - he would like to reunite Marshall, Sams, and their Cupid co-star Jeremy Piven on Veronica Mars.
