Meyer returned to her jewelry making roots in 2004 when Meyer designed her trademark leaf-shaped 18-karat gold charm, which to her represents "turn[ing] over a new leaf". Meyer has extensive Hollywood connections. Her father is Universal Studios President Ron Meyer and her ex husband is actor Tobey Maguire. Her jewelry made its national debut when a Stylist picked out one of Meyer's leaf pendants for Jennifer Aniston to wear in The Break-Up. The exposure led to Meyer founding her own company, Jennifer Meyer Jewelry, and her line of rings, charms, pendants, and necklaces is distributed through such luxury stores as Barneys New York and Net-a-Porter.com. She was named 2007 Jeweler of the Year in the Us Magazine "Hot Hollywood Style" issue. Her heart-shaped locket adorns the neck of Kirsten Dunst's character, Mary Jane Watson, as a gift from her boyfriend, Peter Parker, (Tobey Maguire) in Spider-Man 3. In 2012 Jennifer Meyer Jewelry received an award from the CFDA/Vogue Fashion Fund, and in 2013 Jennifer Meyer was nominated for the CFDA Swarovski Award for Accessories Design. In 2015 Jennifer designed the wedding ring for Jennifer Aniston’s marriage to Justin Theroux, and the company commemorated their 10-year anniversary collaborating with Barneys on a 12-piece ready-to-wear Fall collection—Barneys New York XO Jennifer Meyer.
Meyer met Tobey Maguire in 2003 while he was shooting the movie Seabiscuit at Universal Studios, and they became engaged in April 2006. Their daughter Ruby Sweetheart Maguire was born November 10, 2006. Ruby's middle name comes from a childhood nickname of Meyer's given to her by her grandmother, who died a few months before Ruby's birth. Meyer and Maguire married on September 3, 2007, in Kona, Hawaii. Their second child, son Otis Tobias Maguire, was born on May 8, 2009. In October 2016 Maguire and Meyer announced they were separating.
