Jaymes's adult film career began approximately in 2002. Her stage name is a combination of her real first name, Jessica, and the first name of her then-lover, James. In 2004 she became Hustler Video's first contract model and the "Hustler Honey of the Year". In August 2008 she was the Penthouse Pet of the Month.
Jaymes played a small role in two episodes of the television series Weeds in 2006 and 2007, and made appearances on various reality shows such as VH1's Celebrity Rehab Sober House and HBO's Vivid Valley as well as The Howard Stern Show.
