She appeared in several television series, including The Love Boat (1977), Happy Days (1977), Night Court (1984), Charlie's Angels (1978), Vega$ (1978-1979), B. J. and the Bear (1979), The Jeffersons, Buck Rogers in the 25th Century (1980), Madame's Place (1982–1983), L.A. Law (1986), The Fall Guy (1982), Murder She Wrote (1987) and ALF. She appeared in two episodes of the original Knight Rider (as two characters), and two episodes of The A-Team (again as two characters).
Landers has appeared in several films, including Goldie and the Boxer (1979), The Black Marble (1980), Hellhole (1985), Doin' Time (1985), Deadly Twins (1985), Stewardess School (1986), Armed and Dangerous (1986), Ghost Writer (1989), Club Fed (1990), Dr. Alien (1989), and The Divine Enforcer (1992).
Landers has been married to former Major League Baseball pitcher Tom Niedenfuer since November 1987. They have two daughters: Lindsey, born 1989; and Kristy, born 1991.
Landers has often worked with her sister Audrey, including collaborating with her on the children's show The Huggabug Club (1996), and The Treehouse Club (1997). The sisters were on the cover of the January 1983 issue of Playboy magazine and in a non-nude pictorial. Along with their mother Ruth, they produced the family film Circus Island (2006).