Frost is known for playing the role of Betsy Stewart Andropoulos on the daytime soap opera As the World Turns from 1984 to 1988, a role which was previously played by Actress Meg Ryan. She also played Dr. Jesse Lane in the drama Birdland, Sergeant Helen Sullivan in the crime drama High Incident, Fay Pernovick in the drama Nightmare Cafe, and Claire Stark in the crime drama Shark.
She has also appeared in the cult films Dead Heat (1988), as Randi James and The Ring (2002), as Ruth Embry.
She appeared on Crossing Jordan in the recurring role of Maggie from 2001 to 2006. In recent years she has also guest starred in a number of series including Lost, Boston Legal, Shark, CSI: Crime Scene Investigation, CSI: Miami, and Frasier.
