Ghenea in 2007 has attracted the Romanian media's attention with the release of Il tempo tra di noi videoclip, where she appeared as the girlfriend of the singer. In 2010, Ghenea appeared in the sixth edition of the Italian talent show Ballando con le stelle, her partner becoming the Dancer Simone Di Pasquale. Since 2011, Ghenea has been the image of TRE-Italy mobile company, and has appeared in many commercials with Raoul Bova; also in 2011 Ghenea became the image of the dance clothing DEHA and of the vintage racing cars Mille Miglia. She made in 2011 her debut as Actress in the role of Irina in the Italian film I soliti idioti. Ghenea in 2013 appeared in Dom Hemingway alongside Jude Law. In 2015, Ghenea appeared as Miss Universe in Paolo Sorrentino's drama film Youth. With the Italian actor Gabriel Garko, Ghenea co-hosted and supported Carlo Conti for the 2016 edition of Sanremo Music Festival. She replaced Belen Rodriguez in September 2016 as the face of the luxury brand Vanitas.
Ghenea on 30 December 2015 has stated on Instagram: "Ceausescu was leading a Communist regime, but everyone had something to eat and there wasn't, like now, the abyss between poor and rich".