Collins joined the cast of Mad TV at the beginning of season 4 (Fall 1998) and stayed until the end of season 9 (Spring 2004), despite appearing in only 14 episodes during the ninth season. Her popular stint on the show led her to come back to guest star in 2005 during Season 10, in 2007 during the 300th episode on season 13, final episode of season 14 in 2009 and the 20th anniversary reunion special in 2016. She was also known for trying to stifle laughter during some of her skits much like Harvey Korman on The Carol Burnett Show.
Collins is in remission from a rare form of cancer known as gastrointestinal stromal tumor (GIST). She was diagnosed in spring 2011 when she noticed an odd lump in her abdomen. Said Collins: "I would have done nothing about it. I was 44, feeling healthy, everything was going great for me, but my fiancé, Alex said, ‘You need to get it checked out’". She learned she had a primary tumor in her duodenum and was able to find a Doctor who knew enough to know that she needed to see a specialist.
Collins has been married to actor Alex Skuby since June 2013.They have no children.