She trained as an Actress at the London Academy of Music and Dramatic Art, graduating in 1995. Wise is best known for her work in the British soap opera EastEnders and the Channel 4 comedy Peep Show. On stage, she has had roles in Christopher Shinn's Where Do We Live and in Nina Raine's Rabbit. She also played Rebecca Shaw in the Channel 4 series Derek. In 2015 she portrayed Sylvie in the Mystery miniseries The Enfield Haunting.
