In 1990, Robie made her acting debut as Nadine Hurley in David Lynch's cult television series Twin Peaks. She starred in 22 episodes. In 1991, Robie guest starred on an episode of Baywatch and portrayed the villainous Woman in Wes Craven's cult horror film The People Under The Stairs. The following year, Robie reprised her role as Nadine in David Lynch's prequel film Twin Peaks: Fire Walk with Me (1992), although her scene was deleted. The same year, she guest starred on an episode of the television series Quantum Leap. In 1993, Robie starred in the television film Prophet of Evil: The Ervil LeBaron Story.
In 1994, she guest starred in the television series Viper and Ultraman: The Ultimate Hero before starring in the television film A Place for Annie. In 1995, Robie had a cameo role in Wes Craven's horror comedy film Vampire in Brooklyn. The same year, she had guest roles on the television series Sister, Sister and Star Trek: Deep Space Nine.
In 1996, Robie made her voice-over debut in the video game Zork: Nemesis. The same year, Robie had a guest role on the television series Dark Skies and a supporting role in the film The Glimmer Man. In 1988, she starred as Bernice in the horror film The Dentist 2, Harriet Davidson in the television series C-16: FBI, and had a supporting role in the film Devil in the Flesh. In 2014, Robie's deleted scene from Fire Walk With Me was included in Lynch's film Twin Peaks: The Missing Pieces. In 2017, Robie reprised her role as Nadine in David Lynch's revival series Twin Peaks: The Return.