Parker was born in Durham, North Carolina and attended North Carolina Central University before moving to New York. After guest-starring role on CSI: Miami, in 2006 she has won the series regular role of Darcy Hawkins in the CBS series Jericho. The series was canceled after two seasons, and Parker Jones later appeared on Lost, The Unit, NCIS, Scandal, and also had a recurring roles in 90210 and The Fosters.
In 2014, Parker Jones was cast as one of leads in the Oprah Winfrey Network prime time soap opera, If Loving You Is Wrong. She plays the role of Natalie Henning, the single working mother. The series also stars Edwina Findley, Zulay Henao, Heather Hemmens, and Amanda Clayton. In 2015, she also had the recurring role as detective Claire Bryce in the ShondaLand's legal thriller How to Get Away with Murder, and the following year on Lifetime comedy-drama, Devious Maids.
