After studying at the Faculty of Arts of Poitiers, Dominique Pinon moved to Paris and enrolled at the Cours Simon. In 1981, Jean-Jacques Beineix made him begin in cinema with the movie Diva.
He received the Molière Award for Best Actor in 2004. He is an officer of the Ordre des Arts et des Lettres since 2014.
In 2011, he was the President of the jury for the second Festival International du Film fantastique d'Audincourt.