DeSantis played Heather in Road Trip and Alexandra in Bomb the System in 2002.
In 2003 she portrayed Luis Guzman's daughter on the sitcom, Luis.
In 2005 she played Leticia in the crime/drama movie Carlito's Way: Rise to Power. DeSantis appeared as a young widow and rancher in the 2008 film A Gunfighter's Pledge. In 2009 she played Cuba Gooding Jr.'s wife in the film, The Way of War.
