Leatherhead makes his debut in the 49th issue of IDW Publishing's comic series. He appears very briefly, telling Dr. Harold and Professor Honeycutt that he had some mutagen that could be used to help heal Donatello.
In The Big Blowout, Leatherhead and the other Mutanimals teams up with the Turtles, April, Casey, Karai and Shinigami to defeat Bebop and Rocksteady, who are recruited by Krang and 1987 Shredder.
In the 2003 series, Leatherhead is shown as a friend of the Turtles and is often referred to as "LH." He is voiced by Frederick B. Owens in seasons 2 and 3 and by Gary K. Lewis in season 4 and 7.
Brown returned to plot his creation after 19 years in the September 2007 issue of Tales of the TMNT. Out for a swim, Leatherhead encounters a group of aliens called Sigmurethites and attacks them. The alligator-man's Utrom guardian Dr. X, a.k.a. Xeinos the Utrom, also appears in this issue in a female scientist's exoskeleton.
Leatherhead appears in the 2012 Teenage Mutant Ninja Turtles TV series, voiced by Peter Lurie and again an ally to the Turtles.
Leatherhead also appears as a boss in the 2014 3DS game voiced by André Sogliuzzo.
