Hyser appeared in various films in the early 1980s, the last of which was the 1985 comedy, Just One of the Guys. She then mainly guest-starred in television series, including a recurring role in L.A. Law as Jimmy Smits's girlfriend.
She was featured prominently in the music video for "I Can Dream About You" by Dan Hartman. In the video, Dan Hartman is a bartender pining for a beautiful customer played by Hyser. She was also featured in the music video for the 1994 song "Pincushion" by ZZ Top, a single from their 1994 album Antenna.
Hyser has become a spokeswoman for the Harold Robinson Foundation, which provides a free summer camp for inner city and underprivileged children. In 2011, Hyser appeared in a small role in CSI: Crime Scene Investigation as a woman who masquerades as a man, a role she described as an homage to Just One of the Guys.
