Gable has appeared in four Broadway productions including the 1974 revival of Candide for which she was nominated for a Tony Award for Best Featured Actress in a Musical for her portrayal of the Old Lady. She was featured as Snooks Keene in the infamous Broadway disaster, Moose Murders, which opened and closed on the same night in 1983. She also appeared in a replacement cast of the off-Broadway revue Jacques Brel is Alive and Well and Living in Paris. In November 2012 she starred in the lead role of "Marie" in the world premiere of Bill C. Davis' "All Hallowed" at the Waco Civic Theatre in Waco, Texas under the direction of George Boyd.
On television, Gable played detective Battista on the sitcom Barney Miller in the 1976, third season. She was also in the cast of the short-lived 1977 revival of Rowan & Martin's Laugh-In. In 1979 she appeared as "Rhoda Rooter" on the live-action Hanna-Barbera TV specials Legends of the Superheroes. From 1978 to 1981, she was regular member In the syndicated variety series Sha Na Na. In 1980s, she guest starred in episodes of popular series including Miami Vice and Kate & Allie, and well as had small parts in films Brenda Starr and She-Devil (both 1989).
From 1994 to 2004, Gable played Estelle Leonard of the Estelle Leonard Talent Agency, the agent of the Matt LeBlanc character Joey Tribbiani, on the NBC sitcom Friends, with her character dying in 2004. She played a nurse on the same show in season 1, episode 23. She also appeared in a recurring role in the HBO comedy series Dream On from 1990 to 1996 playing Libby Friedman.