DeVito was born in New York City, New York, the daughter of actors Danny DeVito and Rhea Perlman. She also has two younger siblings, a sister, Grace Fan DeVito (born March 1985) and a brother, Jacob Daniel DeVito (born October 1987).
In 2008, DeVito starred as Anne Frank in a production of Anne Frank at the Intiman Theatre in Seattle, Washington.
Her first major movie role was the 2009 film Leaves of Grass. She portrayed the daughter of Danny DeVito's character in the 2016 film The Comedian starring Robert De Niro.