In 2007, Ruff received two nominations for the American Anime Awards, one for Best Actress for her work in Bleach and Lupin the 3rd, and one for Best Actress in a Comedy for Lupin the 3rd, but lost to Mary Elizabeth McGlynn and Debi Derryberry, respectively. In 2009, the Society for the Promotion of Japanese Animation (SPJA; whom organized the Anime Expo) gave her an SPJA Industry Award for Best Voice Actress (English) for her work as Rukia Kukichi in the Bleach movie Memories of Nobody.
After moving to Los Angeles, she worked with some Directors on looping and voice work for films and TV shows. In an Anime Dream interview, Ruff credits Richard Epcar, Steve Kramer and Michael Sorich for training her to dub anime. In the Digimon series, she was referred by Director Mary Elizabeth McGlynn to audition for Lopmon and Antylamon in the third season, and in the fourth season she landed the lead part of Zoe. Ruff said that it was her first show that made it to TV, and a show that let her "work my acting muscle". She played tomboy-ish characters Miyao in Carried by the Wind: Tsukikage Ran and Kiki Rosita in Mobile Suit Gundam: The 08th MS Team.
