In 2005, she returned to acting with Ram Gopal Verma's crime drama D, in which she played Randeep Hooda's girlfriend. She also featured in Verma's Sarkar the same year. In 2008, she appeared in Rumi Jaffery's God Tussi Great Ho as Salman Khan's sister. In 2009, she starred in The Stoneman Murders alongside Kay Kay Menon. Film critic Taran Adarsh in his review for the film called her a "complete natural". She also had supporting roles in Benny and Babloo (2010), Knock Out (2010), Allah Ke Banday (2010), Shaitan (2011) and PK (2014).
In television, she has featured in Sony Entertainment Television's medical drama Kuch Toh Log Kahenge (2011-13) as Dr. Mallika and in Life OK's Tumhari Paakhi (2013-14) as Lavanya. She did a cameo in Star Plus's 'Diya Aur Baati' as Mehak. She was a part of an International play 'Nirbhaya' (2014- 2016). Rehman also did a critically acclaimed Malyalam film 'Take Off' (2017). She appeared in campaigns for brands like Kaya Skin Clinic, Asian Paints, Saffola salt and others. Currently she is busy with her two plays 'Bade Miyan Deewane' & 'Phir Se Shadi'.
