She is grand niece of famous Writer Khushwant Singh, her great great uncle and Kushwant's father Sobha Singh, was a witness for prosecution in the 1929 Assembly Bomb Case, in which he identified and testified against Bhagat Singh and Batukeshwar Dutt after they threw bombs at the Delhi assembly in 1929, subsequently, Shaheed Bhagat Singh, Sukhdev and Rajguru were sentenced to death for their role in the assassination of Saunders.
For 10ml Love, which is based on Shakespearean play Mid Summer Night's Dream, Tisca was nominated for Best Actress at the 11th Annual New York Indian Film Festival. Her film Ankur Arora Murder Case written and produced by Vikram Bhatt released in May 2013. Her other notable films are Anup Singh's Qissa with Irrfan Khan released in 2013 has travelled to over 20 festivals, winning over almost all top awards and much appreciation from audiences and critics and Rahasya by UVI Film Production Pvt. Ltd. She has worked in the Marathi film Highway with Umesh Kulkarni and Hindi and Tamil remakes of Marathi film Kaksparsh directed by Mahesh Manjrekar.
Starting her Television stint with the immensely popular short film format called Star Bestsellers, Tisca starred in two popular films, ‘Ek Shaam Ki Mulaqat’ and ‘Hum Saath Saath Hain Kya?’. This paved the way for leading parts in a popular show, Balaji Telefilms' ‘Kahaani Ghar Ghar Kii’(Star TV), ‘Astitva...Ek Prem Kahani (Zee TV)’ and ‘Sarrkkar: Risshton Ki Ankahi Kahani (Zee TV)’.She hosted a consumer grievances show on (Star News) called Main Hoon Na. Tisca hosted Prayschit - Gunahon Ke Zakhm on Sony Entertainment Television (India) where she got a chance to reveal the transformation that Criminals go though after or during their prison sentence; the show has generated high TRP ratings. She recently starred in 24, a remake of the popular American series of the same name, produced by Anil Kapoor Films, directed by Abhinay Deo, which was premiered on Colors. Her intense performance was much lauded and made her a household name. The series won Best Ensemble Cast.